In 1886, a one-story frame Chapel was built on the present property for Sabbath services and weekly prayer meetings.  1886 also saw the First Presbyterian Church of Frankford extending these worshipers a helping hand by naming the church one of its missions.

In October of 1888, an independent Presbyterian Church was organized by a committee as the Presbytery of Philadelphia North.  Twenty three charter members founded the Church having transferred from Disston Memorial Presbyterian Church, Bridesburg Presbyterian Church, Frankford Presbyterian Church and other Presbyterian affiliations.

From 1915 to 1931, Rev. Dr. William A. Cook served this church.  Under his Pastorate the present sanctuary was built.  The basement as it is today was the first structure to be completed and served as a sanctuary for three years.  The sanctuary as it now exists was completed and dedicated in 1925, hence the 1920 date on the church cornerstone.

Wissinoming Presbyterian, a mission church at its beginning, ultimately became a sponsor for the mission congregation located at Harbison and Brous Avenues - Westminster-Mayfair Presbyterian Church.

The 1941 building campaign for an educational building was interrupted by WWII.   By 1946, the white frame building on Howell Street which had served for sixty years, initially as a sanctuary, then later as a Sunday School building was demolished.   In its place the present Christian Education Building was erected in 1946-7.